Wednesday, December 25, 2019
The At The Bank Until 11 - 2144 Words
Although we were not scheduled to meet Luisa at the bank until 11:00 oââ¬â¢clock, we arrived in Marsciano early the next morning to wander around town. As soon-to-be home-owner and part time residents, we looked at everything from a new perspective. Marsciano was going to be our home town, where we would attend community events, the weekly market, shop, dine in restaurants and make new friends. As we did with Johannes, we parked the car near the community elevator and took the lift up to the historic center. We acknowledged passerby when our eyes met and bid them Bouna giornata; a Good day. We window-shopped at the boutiques on the Corso Umberto, somewhat surprised at the high quality merchandise for sale in such a humble village.â⬠¦show more contentâ⬠¦I felt as if we were in a charming Italian movie. How could this possibly be real? Our lunch was more delicious than the first time we dined at this restaurant and our conversation was more spirited. We vowed to take I talian lessons as soon as we returned to California. Instead of relinquishing Power of Attorney to Casambiente, Vince was bound and determined to attend the Deed Signing ceremony in Perugia in May which meant that he would sign on my behalf so that I could accumulate my vacation time until the Fall, when we planned to furnish the apartment and move in. I asked Vince to paint each room, acquire a bed, a table and chairs while he was there, so that when I arrived in September the apartment was spic-and-span clean and we had a place to sleep and eat. It was gently raining and already dark when we arrived at the front door of BB Garibaldi in the early evening. Vince inserted the key into the front door lock, when much to his surprise, he felt the key snap in two as he turned it to unlock the door, leaving the stem in the keyhole. ââ¬Å"Oh great! Now what do we do?â⬠Vince said as he pulled the remaining part of the key out of the lock and looked at it bewildered in his hand. à ¢â¬Å"I donââ¬â¢t knowâ⬠I answered. ââ¬Å"David emphatically asked us not to ring the doorbell because his grandmother was always asleep. Letââ¬â¢s try knocking on the door or calling his name. I believe thatââ¬â¢s his balcony.â⬠ââ¬Å"Iââ¬â¢m not going to yell out his name in the streetâ⬠Vince
Tuesday, December 17, 2019
Biography of Isaac Newton Essay - 587 Words
Sir Isaac Newton was born in Lincolnshire, near Grantham, on December 25, 1642. His education took place at Trinity College, in Cambridge where he lived from 1661 to 1696. Here is where he studied physics and astronomy, and created calculus. Newton became interested in mathematics in the autumn of 1663 when he tried to read an astrology book but could not understand it because he had little knowledge of trigonometry and geometry. What got his mind going was when he read that parallelograms upon the same base and between the same parallels are equal. He then returned back to the astronomy book with a greater understanding and interest. In the summer of 1665, the plague closed down the University he was attending and duringâ⬠¦show more contentâ⬠¦Before his time, people had believed that white light was a basic single entity, but the chromatic aberration in a telescope lens convinced him otherwise. With this hypothesis, he wrongly concluded that telescopes using refracting lense s would always suffer chromatic aberration; therefore he constructed a reflecting telescope. He delayed the publication of a full account of his optical researches until 1704, it dealt with: investigations of the colors of thin sheets, Newtonââ¬â¢s rings, and diffraction of light. However Newtonââ¬â¢s greatest achievement was his work in physics and celestial mechanics, which climaxed with the theory of universal gravitation. By 1966, he had created his 3 laws and of motion and also discovered the law giving the centrifugal force on a body moving uniformly in a circular path; although his understanding of mechanics of circular motion was incorrect. Newton imagined that the Earthââ¬â¢s gravity influenced the Moon, counter-balancing its centrifugal force. From his law of centrifugal force and Keplerââ¬â¢s third law of planetary motion, Newton deduced the inverse-square law. In 1687, Newton published the Philosophiae naturalis principia. The book is considered the greatest scientific book ever written. In it he analyzes the motion of bodies in resisting and non-resisting media under the action of centripetal forces. The results were applied to orbiting bodies, projectiles, pendulums, and free-fallShow MoreRelated Biography of Isaac Newton Essay1127 Words à |à 5 Pages Isaac Newton was a key figure in the development of the age of reason. His achievements revolutionized physics and mathematics and he has been recognized as an undisputed genius (Gardner 13). Newton was a intriguing individual who played an important role in the advancement of the scientific community of his time and of today. Newton was born on Christmas day in 1642 to a widowed farming mother. When he was three his mother left him in the care of his grandmother, so she could remarry (WestfallRead MoreBiography Report On Isaac Newton1767 Words à |à 8 Pages PHYSICS REPORT Melissa Kouamo Physics 2425 Dr. Lee Estep Fall 2016 BIOGRAPHY REPORT ISAAC NEWTON Among all the scientists I have had a chance to learn about, one of the famous is known as Isaac Newton, born in 1642 and deceased in 1742. Generally recognized as a physicist, he is proudly known for his work in a lot of domain such as mathematics, optics and motion which are all parts of physics. Born prematurely on Christmas day, he was fatherless and barely three years old when his mom leftRead MoreBiography of Sir Isaac Newton Essay1365 Words à |à 6 Pages Isaac Newtons life can be divided into three quite distinct periods. The first is his boyhood days from 1643 up to his appointment to a chair in 1669. The second period from 1669 to 1687 which was the highly productive period in which he was a professor at Cambridge University. The third period (nearly as long as the other two combined) saw Newton as a highly paid government official in London with little further interest in mathematical research. Isaac Newton wasRead MoreBiography of Sir Isaac Newton Essay1142 Words à |à 5 PagesIsaac Newton is considered by many to be one of the most influential people in human history. Born on January 4th 1643 (New Style calendar, December 25th 1642 on the Old Style) at Woolsthorpe Manor in Woolsthorpe-by-Colsterworth, Isaac Newton was involved in the fields of physics, math, astronomy, among other fields. Best known in the Physics community for his three laws of motion as well as his description of universal gravitation, he was also responsible for much during his life. Born three monthsRead MoreBiography Of Isaac Newton s Life1606 Words à |à 7 PagesAmong all the scientists I have had a chance to learn about, one of the famous is known as Isaac Newton, born in 1642 and died in 1742. Generally recognized as a physicist, he is proudly known for his work in a lot of domain such as mathematics, optics, and motion which are all parts of physics. Born prematurely on Christmas day, he w as fatherless and barely three years old when his mom left him as his maternal grandmotherââ¬â¢s to get remarried and build a second family: challenging childhood but fullRead MoreBiography Of Isaac Newton s Life1274 Words à |à 6 PagesIsaac Newton It was the 4th of January 1643, Christmas Day according to the Julian Calendar, when one of the greatest minds of science was born, Isaac Newton. He was born and raised in the town of Woolsthorpe, United Kingdom. Born without a father and raised by his maternal grandmother after his mother left to remarry a wealthier man, since three years old, Newton lead an unforgettable childhood. Newtonââ¬â¢s mother came back when her second husband died. His motherââ¬â¢s return in 1653 forced Newton toRead MoreBiography Of Sir Isaac Newton s Life827 Words à |à 4 Pages motion or gravity until Newton came around and discovered them. I know one question that I have is what would our world be like today if these important discoveries were not found? Sir Isaac Newton was simply a genius. He discovered many important aspects that are used in the modern world on a daily basis. He was very passionate about learning and his innovations changed the world. The first innovation that Newton brought to our world was the discovery of light. Newton said that white light is madeRead MoreBiography Of Isaac Newton s Three Laws Of Motion1003 Words à |à 5 PagesIsaac Newton was an English mathematician, astronomer, and physicist who had developed his three laws of motion by the age of 23. He was born in 1642 the same year the Italian astronomer Galileo Galilei died. Galileoââ¬â¢s work helped to influence or set the stage for the development and creation of Newtonââ¬â¢s three laws. Newtonââ¬â¢s three laws of motion consists of the first law which is the concepts of inertia, second law which is relating acceleration to its cause and lastly the third law which is actionRead MoreTime And Date Of Birth790 Words à |à 4 Pagesborn on Jan uary 4, 1643, in Woolsthorpe, England (Isaac Newton.). and (Isaac Newton, reluctant genius.). This was no ordinary being as he would change the world and our perception of the universe forever. Isaac was his name, and he was an English-born physicist and mathematician (Isaac Newton.). Living Conditions He was the only son of a yeoman farmer, whoââ¬â¢s name was also Isaac Newton, that sadly died three months before he was born (Isaac Newton.). ââ¬Å"The small baby was very tiny and weak and wasRead MoreThe Achievements Of Isaac Newton1368 Words à |à 6 Pagesscientific life that we live in today. One of the most influential scientists would be that of Sir Isaac Newton. Newton was a prominent philosopher, astronomer, mathematician, physicist, and scientist during the 17th century. The accomplishments completed within his life helped in contributing and shaping the fact that he was one of the single-most influential scientists of his time. On January 4, 1643, Isaac Newton was born in the Woolsthorpe, Lincolnshire, England colony. His birth date, using the ââ¬Å"oldââ¬
Monday, December 9, 2019
Business Plan Joes Vinegar Essay Example For Students
Business Plan Joes Vinegar Essay Joeââ¬â¢s Original Seasoned Vinegar MARZ Foods, LLC Executive Summary MARZ Foods, LLC is a manufacturer of 100% all natural seasoned vinegar that is healthy and delicious. The first product we will launch is Joeââ¬â¢s Seasoned Vinegar. The recipe was handed down in the ownerââ¬â¢s family for at least four generations, and we are ready to share it with the world. This is the first condiment of its kind and currently it has no competitors. Joeââ¬â¢s has several marketing points. For one, thereââ¬â¢s no other product like it. Through the use of a food broker and taste sampling, we are confident our product will be a huge success. Second, the target market is huge. Nearly every person of grocery-purchasing age will have a reason to try Joeââ¬â¢s Seasoned Vinegar. Whether it is a young person that is interested in great tasting zero calorie foods, a parent that would try anything to get their children to eat vegetables, or an elderly person that needs no-salt condiments, Joeââ¬â¢s Seasoned Vinegar is the product of choice! This yields a local target market of over 75,000 and over 110 million nation wide. It is possible that our seasoned vinegar is really good for you! Studies show that apple cider vinegar and garlic, two of Joeââ¬â¢s Seasoned Vinegarââ¬â¢s ingredients, help lower high blood pressure, lower cholesterol, prevent blood clots, prevent cancer, and protect against bacterial and fungal infections. Lastly, the product has an incredible lab-tested shelf life of 24 months. This means there is minimal risk for both the retailer or for MARZ Foods, LLC. The owners/operators of MARZ Foods, LLC are Nicole Martin and Barry Muslow. Barry is in the process of being trained by Johnson Wales as a chef and has owned and operated several successful entrepreneurial ventures. Nicole has over 8 years in project management experience. Nicole and Barryââ¬â¢s dedication and past experience will ensure sustainable growth for MARZ Foods, LLCââ¬â¢s product line. MARZ Foods, LLC believes we will reach profitability by the end of 2008 and forecasts nearly one million dollars in net profit in just two years. The financials within the plan further reinforce the exciting projected business. 1. Objectives MARZ Foods, LLC has several objectives that they will achieve within the first three years. The first is an increase in sales reaching over one million dollars by the end of 2009. MARZ Foods, LLC will strive to get gross margins to be above 50%. MARZ Foods, LLC hopes to be selling mass quantities to grocery and wholesale stores through the use of a food broker by the third quarter of 2008. Sales should reach over one million dollars by the end of 2009. 2. Mission MARZ Foods, LLCââ¬â¢s mission is to provide delicious condiments that are 100% all natural, organic, healthy, and delicious. 3. Keys to Success â⬠¢ Delivering high quality 100% natural products at an affordable price. â⬠¢ Producing products with a long shelf life. Providing service, support, and a better than average margin to our retailers. â⬠¢ Increasing net cash flow to over ten million dollars by the end of 2010. 1. The Company MARZ Foods, LLCââ¬â¢s mission is to provide delicious condiments that are 100% all natural, organic, healthy, and delicious. The launch product is an old family recipe that tastes amazing and may have medicinal side effects such as being able to help lower high blood pressure (this claim has not been substantiated by any medical professional or group). The immediate goals are to produce and sell our product in the local farmersââ¬â¢ markets and specialty stores, then to incorporate selling of the product at in-state festivals, and eventually expanding to grocery chains and wholesale clubs state and nation wide. MARZ Foods, LLC will continue R activities to experiment with new flavors to guarantee the long-term success of the company. 1. Company Ownership MARZ Foods, LLC is a privately held corporation owned in total by its co-founders, Nicole Martin and Barry Muslow. 2. Company History MARZ Foods, LLC has been hindered only by the lack of working capital it had in its initial stages of setup and operation. Sales are growing steadily. In order to make significant headway in this area, additional capital is needed to pay for a food broker to market our product and the initial production run at the manufacturing plant. According to Net Industry, a food broker is a sales agent that negotiates sales for producers and manufacturers of food and food products. Producers and manufacturers often sell through food brokers rather than directly because it saves the cost of paying a sales staff to market their products. Coincidentally, since food brokers represent a large number of producers, the wholesalers and retailers also save time and money by dealing with one broker rather than with many manufacturers representatives. By utilizing a food broker, demand for our products will dramatically increase and we will need to utilize a manufacturing plant to produce our product. The initial production run will be costly; however the cost will significantly decrease after the first run. 3. Past Performance à Past Performance | | | | | |2006 |2007 |2008 | |Sales |$0 |$2,700 |$900 | |Gross Margin |$0 |$1,350 |$450 | |Gross Margin % |0. 00% |200. 00% |200. 0% | |Operating Expenses |$0 |$4,525 |$420 | |Inventory Turnover (per 50 |0 |3 |2 | |cases) | | | | |à |à |à |à | |Balance Sheet |à |à |à | |à |2006 |2007 |2008 | |Current Assets |à |à |à | |Cash |$0 |$0 |$50 | |Accounts Receivable $0 |$0 |$0 | |Inventory |$0 |$0 |$1,725 | |Other Current Assets |$0 |$0 |$0 | |Total Curre nt Assets |$0 |$0 |$1,775 | | | |Long-term Assets |à |à |à | |Long-term Assets |$0 |$0 |$0 | |Accumulated Depreciation |$0 |$0 |$0 | |Total Long-term Assets |$0 |$0 |$0 | |Total Assets |$0 |$0 |$1,775 | | | |Current Liabilities | |Accounts Payable |$0 |$0 |$0 | |Current Borrowing |$0 |$0 |$0 | |Other Current Liabilities |$0 |$0 |$0 | |(interest free) | | | | |Total Current Liabilities |$0 |$0 |$0 | |Long-term Liabilities |$0 |$0 |$0 | |Total Liabilities |$0 |$0 |$0 | |à | |Paid-in Capital |$0 |$0 |$5,000 | |Retained Earnings $0 |$0 |($3,145) | |Earnings |$0 |$0 |$0 | |Total Capital |$0 |$0 |$1,855 | |à | |Total Capital and |$0 |$0 |$1,855 | |Liabilities | | | | |à | |Other Inputs |à |à |à | |Payment Days |0 |0 |0 | |Sales on Credit |$0 |$0 |$0 | |Receivables Turnover |0 |0 |0 | 4. Company Locations and Facilities Currently we have one location in Melbourne, FL. It includes the production area and warehouse area. We currently pay for only the space we need, and can expand to retain much more product. However, once the food broker has marketed our product in markets nation wide, the demand will increase. When we can get those orders in, we are prepared to subcontract a manufacturer who will produce our product for us at a minor increase of cost. The subcontractor will require one weekââ¬â¢s notice and in that time we will be able to provide the productââ¬â¢s supplies. Both our production practices and that of the subcontractor provide a high quality, healthy, delicious food product. 2. The Product For many years, the food industry was dominated by fast and easy food, regardless of how unhealthy those foods were. With obesity at an all time high, and heart disease being the number one killer of people in the United States (CDC 2008), people are now taking a closer look at the foods and condiments they intake. People are looking for heart-healthy, salt, and fat free condiments to season their food. 1. What is Joeââ¬â¢s Seasoned Vinegar Joeââ¬â¢s Seasoned Vinegar is a simple blend of apple cider vinegar, garlic, and spices that produces a very complex and interesting flavor. The combination of garlic and spices transforms the taste of the apple cider vinegar in a truly unexplainable way. Itââ¬â¢s an old family recipe that has been passed down for at least four generations, and is absolutely delicious. This is a perfect example of the whole product being more than just the sum of its parts. Joeââ¬â¢s Seasoned Vinegar contains no calories or traditional nutritional value. It can be used to marinate meat, fish, poultry, and vegetables. It can be used as a salt-free additive to vegetables, beans, meat, poultry, and fish. A Journey Through Writing EssayMARZ Foods, LLC plans to subcontract the manufacturing of their products once product demand reaches a level beyond their ability. MARZ Foods, LLC does not plan to purchase capital equipment or any real estate. Therefore, there are three different product exit strategies. The first strategy is our most profitable, which is to license the production of our product to another food production company. The second is to sell our trade secrets to another food production company. Lastly, should MARZ Foods, LLC decide to end production, we could sell any left over product at any price necessary to remove it from our subcontractorââ¬â¢s warehouse. 5. Organizational Structure 1. Management Summary MARZ Foods, LLC was founded by Nicole Martin and Barry Muslow and has always operated without the burden of payroll or salary expenses. Barry Muslow, President Barry assists with preparation and production of the seasoned vinegar, maintains inventory of the finished product, is responsible for packing and shipping and/or delivery, and assists with record keeping. Barry is responsible for marketing and promoting Joeââ¬â¢s Seasoned Vinegar locally. Nicole Martin, Vice President Nicole is currently responsible for preparation of the seasoned vinegar including preparing, bottling, labeling the product. She also maintains inventory of and purchases all supplies. Nicole maintains company and financial records. To date, neither owner has collected a paycheck from the company. However, as orders are processed and goals are met, plans are to subcontract the production to a manufacturer to take production out of our hands. Once sales reach a specific point, we plan to pay each owner as full time employees. We are forecasting this to transpire in the second quarter of 2009. 2. Organizational Structure MARZ Foods, LLCââ¬â¢s planned organization calls for product development, finance, and administration, which will continue to be handled by the owners. Production will be subcontracted out to a manufacturer. A food broker will handle sales and marketing. 6. Financial Plan MARZ Foods, LLC is forecasting very rapid growth for Joeââ¬â¢s Seasoned Vinegar this year. Although this may seem ambitious based on historic sales, this rate of growth is due to the employment of a food broker. The food broker we have selected has proven sales, references have been researched in full, in major food stores such as Kroger, Roche Brothers, Shawââ¬â¢s, and B. J. ââ¬â¢s Wholesale Club. 1. Important Assumptions The financial plan depends on important assumptions, most of which are shown in the following table. The key underlying assumptions are: â⬠¢ We assume a slow-growth economy, without major recession. â⬠¢ We assume, of course, that there are no unforeseen changes in the consumer market to make products immediately obsolete or out of favor (or not increasing in popularity). We assume access to equity capital and financing sufficient to maintain our financial plan as shown in the tables, addendum, and additional documentation |General Assumptions | |à |2008 |2009 |2010 | |Plan Month |1 |2 |3 | |Current Interest Rate |3. 00% |3. 00% |3. 00% | |Long-term Interest Rate |0. 00% |0. 00% |0. 00% | |Tax Rate |0. 00% |0. 00% |0. 00% | 2. Key Financial Indicators The most important financial factor for MARZ Foods, LLCââ¬â¢s Joeââ¬â¢s Seasoned Vinegar product is the ability to procure financing that will allow us to progress to the next level. As demand for our product increases, our production cost will decrease due to purchasing supplies at increased volumes. This will lower our product cost and will enable us to pass our savings on to our customers and through to the consumers. 3. Break Even Analysis The break-even analysis shows that MARZ Foods, LLC has a good balance of fixed costs and sufficient sales to remain successful. Purchasing supplies in larger volumes will allow us to further reduce our break-even point and add to our goal of increasing the margin on our product. 4. Projected Profit and Loss We expect to close out this year with over $160,000 in sales, and to increase our sales to more than $14 Million per year by 2010, with comfortable net profit. Pro Forma Profit and Loss | |à |2008 |2009 |2010 | |Sales |$162,000 |$1,671,769 |$14,905,659 | |Direct Costs of Goods |$70,000 |$557,256 |$4,258,759 | |Other |$0 |$0 |$0 | |à | | | | |Cost of Goods Sold |$70,000 |$557,256 |$4,258,759 | |à |à |à |à | |Gross Margin |$92,000 |$1,114,513 |$10,646,900 | |Gross Margin % |76. 09% |50. 00% |40. 00% | |Expenses | |Payroll $9,600 |$43,500 |$72,800 | |Sales and Marketing and |$6,480 |$50,153 |$298,113 | |Other Expenses | | | | |Utilities |$4,000 |$5,000 |$6,000 | |Insurance |$2,000 |$2,200 |$2,400 | |Rent |$7,680 |$30,720 |$30,720 | |Other |$1,000 |$1,200 |$1,400 | |à | | | | |Total Operating Expenses |$30,760 |$132,773 |$411,433 | |à |à |à |à | |Profit Before Interest and |$61,240 |$981,740 |$10,235,467 | |Taxes | | | | |EBITDA |$61,240 |$981,740 |$10,235,467 | |à |à |à |à | |Net Profit |$61,240 |$981,740 |$10,235,467 | |Net Profit/Sales |37. 0% |58. 72% |68. 67% | 5. Projected Cash Flow We expect to manage cash flow over the next three years with the assistance of a Small Business Administration supported loan of $100,000. This financial assistance is required to provide the working capital to meet the current needs while providing a solid foundation to b uild the growth of the company and its products. This will allow the company to meet and exceed sales projections, gross margin, and return on investment. As shown by the cash flow in the table, we expect a healthy growth in net worth through the end of the plan period. |Pro Forma Cash Flow |à |2008 |2009 |2010 | |Cash Received |à |à |à | |Cash from Operations |à |à |à | |Cash Sales |$162,000 |$1,671,769 |$14,905,659 | |Subtotal Cash from Operations|$162,000 |$1,671,769 |$14,905,659 | |Additional Cash Received |à |à |à | |Sales Tax, VAT, HST/GST |$0 |$0 |$0 | |Received | | | | |New Long-term Liabilities |$100,000 |$0 |$0 | |Sales of Other Current Assets|$0 |$0 |$0 | |New Investment Received |$0 |$0 |$0 | |Subtotal Cash Received |$262,000 |$1,671,769 |$14,905,659 | |à |à |à |à | |Expenditures |2008 |2009 |2010 | |à |à |à |à | |Expenditures from Operations |à |à |à | |Total Operating Expenses; |$70,000 |$557,256 |$4,258,75 9 | |Cash Spending and Bill | | | | |Payments | | | | |Subtotal Spent on Operations |$70,000 |$557,256 |$4,258,759 | |à |à |à |à | |Additional Cash Spent |à | à | |Sales Tax, VAT, HST/GST Paid |$0 |$0 |$0 | |Out | | | | |Principal Repayment of |$3,650 |$5,680 |$6,350 | |Current Borrowing | | | | |Other Liabilities Principal |$0 |$0 |$0 | |Repayment | | | | |Long-term Liabilities |$6,500 |$15,850 |$15,850 | |Principal Repayment | | | | |Purchase Other Current Assets|$0 |$0 |$0 | |Purchase Long-term Assets |$0 |$0 |$0 | |Dividends |$0 |$0 |$0 | |Subtotal Cash Spent |$80,150 |$578,786 |$4,280,959 | |à |à |à |à | |Net Cash Flow |$181,850 |$1,092,983 |$10,624,700 | |Cash Balance |$181,850 |$1,274,833 |$11,899,533 | Works Cited Thaller, M. (2007) Cool cosmos. Retrieved August 27, 2007, from http://coolcosmos. ipac. caltech. edu/ Barton, Joe (2008) Natural Ways to Lower High Blood Pressure 5 Secrets to Naturally Cure Hypertension. Retrieved March 15, 2008, fr om http://ezinearticles. com/? Natural-Ways-to-Lower-High-Blood-Pressure5-Secrets-to-Naturally-Cure-Hypertensionid=1021462 Census Bureau (1996) Current Population Reports. Retrieved March 15, 2008, from http://www. census. gov/prod/1/pop/p25-1129. pdf Center for Disease Control and Prevention (2008) Heart Disease is The Number One Cause of Death. Retrieved
Monday, December 2, 2019
Mysteries Surrounding Creutzfeldt-Jakob Disease Essays -
Mysteries Surrounding Creutzfeldt-Jakob Disease The Mysteries Surrounding Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease is a killer. What we know is that it wastes no time. Creutzfeldt-Jakob Disease will kill a person within one year of contraction. It is yet unknown how Creutzfeldt-Jakob Disease chooses its victims, but it does seem to have accomplices, known as the spongiform encephalopathies, in the rest of the animal kingdom. It is possible that it may be known what means Creutzfeldt-Jakob Disease uses in order to annihilate its victims, but the theory surrounding that is still controversial. By examining the facts and observing the evidence we shall one day uncover the truth behind this malicious killer. Creutzfeldt-Jakob Disease is a rare neuro-degenerative disease. Creutzfeldt-Jakob Disease is a rare neuro-degenerative disease that leads to the loss of coordination, dementia and death. Death usually occurs within a year of the onset of symptoms. Creutzfeldt-Jakob Disease is a human disease and can be dormant for as long as thirty years. The average age of onset is sixty years, but there are recorded instances of onset as easily as sixteen years and as old as 80 years. It is estimated that, world-wide, between 0.5 and 1 case per million population occurs annually. Increased incidence in some regions of the world has been attributed to the possibility of a genetic predisposition. In the United States the incidence has been reported as being 0.9 deaths per million population attributable to Creutzfeldt-Jakob Disease. This is an inexact figure however, due to the fact that Creutzfeldt-Jakob Disease is not a reportable disease in the United States (Holman) and the Center for Disease Con trol does not actively monitor the disease (Altman). To track the disease the Center for Disease Control has initiated a four-state study of death certificates (Altman), but since death certificates are not always accurate Davanpour) the survey may not provide an accurate assessment. This leaves the true prevalence in the United States and other countries remaining a mystery. Compounding the uncertainty, autopsies are rarely performed on atypical dementia patients (Harrison) because medical professionals fear infection (Altman). The officially reported rate of Creutzfeldt-Jakob Disease incidence is less than one case per million people per year (World). An informal survey of neuropathologists, however, registered a theoretical range of 2 - 21% of all dementia as actually Creutzfeldt-Jakob Disease (Harrison) and hundreds of thousands of Americans suffer from severe dementia every year (Brayne; United). Two other studies average about a 3% Creutzfeldt-Jakob Disease rate among dementia patients (Mahendra; Wade). A preliminary 1989 University of Pennsylvania study showed that 5% of patients diagnosed with dementia were actually dying from Creutzfeldt-Jakob Disease (Boller). It would seem that Creutzfeldt-Jakob Disease is seriously underdiagnosed. The most common misdiagnosis of Creutzfeldt-Jakob Disease is Alzheimer's disease (Harrison). Creutzfeldt-Jakob Disease was even described as ?Alzheimer's in fast forward (Wlalzek).? The symptoms and pathology of both diseases overlap. There can be spongy changes in the brain (a classic effect of Creutzfeldt-Jakob Disease) in Alzheimer's disease, for example, and senile plaques deposited on the brain (a classic effect of Alzheimer's disease) in Creutzfeldt-Jakob Disease (Brown). The causes may overlap as well; epidemiological evidence suggests that people eating meat more than four times a week for a prolonged period have a three times higher chance of suffering dementia than long-time vegetarians (Giem), although this result may be confounded by vascular factors (Van Duijn). Paul Brown, medical director for the U.S. Public Health Service (Gruzen), said that the brains of the young people who died from the new variant Creutzfeldt-Jakob disease in Britain even look like the brains of A lzheimer's patients (Hager). Stanley Prusiner, the scientist who coined the term prion, speculates that Alzheimer's may in fact turn out to be a prion disease as well (Prusiner). In younger victims the disease could look like multiple sclerosis or a severe viral infection, according to Alzheimer's expert Gareth Roberts (Brain). Twenty percent or more of people clinically diagnosed with Alzheimer's disease are found at autopsy to not have had Alzheimer's at all (McKhann). At Yale, out of 46 patients clinically diagnosed with Alzheimer's, 6 were proven to have actually had Creutzfeldt-Jakob Disease at autopsy (Manuelidis). In another post-mortem study 3 out of 12 Alzheimer patients actually died from a spongiform encephalopathy
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